Pharmaceutical Profiling in Drug Discovery for Lead Selection

Edited by: Ronald T. Borchardt, University of Kansas
Edward H. Kerns, Wyeth Research
Christopher A. Lipinski, Pfizer Global R & D (retired)
Dhiren R. Thakker, University of North Carolina
Binghe Wang, Georgia State University

Volume 1 of the upcoming AAPS Press series, Biotechnology: Pharmaceutical Aspects. Based on a 2003 AAPS workshop of the same name, Pharmaceutical Profiling in Drug Discovery for Lead Selection emphasizes the importance of accuracy in the prediction, measurement, and application of physiochemical and ADME properties, not only to guarantee successful lead selection in "hit-to-lead" research but also to avoid the common pitfalls that arise when property information is lacking. Its contributors include highly experienced leaders from both industry and academia, with specialization in advanced methods for in silico, physiochemical, permeability, in vitro, and ADME, as well as in medicinal chemistry applications on pharmaceutical property information. This book is the first volume of the Biotechnology - Pharmaceutical Aspects series.

List Price: $185.00; AAPS Member price: $138.75       Printable Order Form

Supporting Information and Data

• Session I: In Silico Tools
• Session II: Physicochemical Methods
• Session III: Permeability
• Session IV: ADME
• Session V: Applications of Property Information to Lead Selection