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Appropriate Selection of Animal Models and their Use in Drug Development
Wednesday, November 14
7:00 am – 8:15 am
Sunrise Session
ACPE #073-999-07-563-L04
This sunrise session will attract students, academics, and industry colleagues working on the in vitro-in vivo interface, in vivo aspects of drug delivery and/or pharmacokinetics. The goal of this sunrise school is to provide a concise presentation and discussion on the concepts of selection of animal models and their use. The significance and validity of the results generated in an animal model depend on the selection of a suitable animal model. Attention will be concentrated on the key criteria for model selection, which include species selection and dosing selection. Species selection depends on agent sensitivity, similarity to human disease process (pathogenesis), expected end point of the study, manipulations required and the cost of animals. Discussion of these criteria and their relationship to the commonly used animal models like mice, rat, guinea pig and rabbit will help the student in designing appropriate experiments. Dosing selection can be a serious challenge while working with animal models. The dosing criterion includes not only the dose levels, but also the route of delivery, therapeutic level and dosing interval. Discussion of these methods will be helpful to troubleshoot the problems. Defining the control group for the study will be the final point examined. This will include defining necessary control groups, methods for randomly assigning the study groups, determining the number of animals needed per group and evaluating the actual response of the animal experiments.
Moderators
Carol Davis, Ph.D.
Davis Consulting and Training
Viswatej Vemulapalli, Ph.D.
Mercer University
Speaker
Ralph E. Parchment, Ph.D.
NCI – Frederick Cancer Research Facility