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Marine Natural Products as Candidates for Clinical Development*
Tuesday, November 13
2:00 pm – 4:30 pm
Symposium
ACPE #073-999-07-552-L04
The sea is a rich and growing source of pharmacologically active compounds produced by microbes, plants and animals, both vertebrates and invertebrates. Lead compounds and their analogs displaying a variety of pharmacologic activities have been described in the literature. One of the most promising and challenging areas of interest relating to natural products from the marine environment is in the field of oncology, with several structurally diverse compounds in various stages of clinical development. The discovery of numerous peptides, carbohydrates and products of other biosynthetic pathways has been described along with the intricate details of their mechanisms of action. Methods in combinatorial chemical synthesis of complex, optically active agents have provided a facile means to the total synthesis of these agents in quantities large enough for development and practical use in the clinic. This symposium will introduce the audience to the discovery of marine natural products and their analogs with activity against cancer, the challenges and intricacies behind their synthesis as pure compounds, analysis of pharmacologic activity and their development for use in the clinic.
Moderator
Robert L. Chapman, Ph.D.
Midwestern University Chicago College of Pharmacy
Discovery of Marine Natural Products
William Fenical, Ph.D.
University of California, San Diego
Marine Pharmacology: A Critique of the Preclinical and Clinical Literature
Alejandro M. Mayer, Ph.D.
Midwestern University
Marine Natural Products in Clinical Trials
David J. Newman, Ph.D.
National Institutes of Health
Development of Conotoxins as Clinical Candidates
Baldomero Olivera
University of Utah
*Session tentatively scheduled to be recorded.
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