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CPTR Open Forum
Thursday, November 15
1:30 pm – 5:00 pm
POINT/COUNTERPOINT
Topic#1: 'Individualized' (PK/PD-guided) but not 'personalized' (pharmacogenetic-guided) is a better approach to dosing of medicines that 'one-dose-fits-all'
Topic #2: Concentrations are better than dose for predicting drug response
Everyone from leading pharmaceutical scientists to CEO's to influential regulators is touting personalized medicine as the wave of the future. But just how soon will that wave arrive (if ever) and what kind of impact will have? Has pharmacogenetic-guided dosing knocked PK/PD-guided dosing off the track as the best approach to drug dosing? Or does individualized dosing (based on measured concentrations or effects) still have gas in the tank?
What about predicting drug response? With regard to dose vs concentration as descriptors of drug effect, and the use of doses still be in line with a target concentration based strategy? Can the challenges associated with the use of plasma concentrations such as noise from measurement error model misspecification be met? Or, can we focus on a more pragmatic dose-response relationship as an adequate predictor of drug response?
MODERATOR
Carl C. Peck, MD
University of California, San Francisco
SPEAKERS
Nicholas HG Holford, MBCB, FRACP
University of Auckland
Other Speakers to be Announced
An additional fee is required to attend the CPTR Open Forum. To register, select the appropriate registration fee under Special Events section of the registration form.
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