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New Paradigms in the Field of Chemical Penetration Enhancers
Wednesday, November 14
8:30 am – 11:00 am
Wednesday Morning Symposia are Funded by a Grant from
Symposium
ACPE #073-999-07-564-L04
Skin offers both tremendous opportunities and challenges for systemic delivery of pharmaceuticals. Chemical penetration enhancers (CPEs) provide several advantages over device-based transdermal drug delivery, still their progress has been limited due to their potential to irritate the skin. In this symposium, a distinguished panel of speakers in the field of transdermal delivery will talk about new technologies and novel testing paradigms in developing CPE’s for transdermal products. Starting with an overview of CPE’s, their current status and limitations, and vision of future trends for CPE’s in transdermal products. New technologies in the high throughput screening of CPE’s and CPE combinations, discovery and structure-activity relationship of novel CPE’s, and genomics- and proteomics-based experimental approaches to understand the fundamental mechanisms that lead to toxicology of CPE’s are some of the topics that will covered. Finally the panel will discuss opportunities and limitations of applications of these paradigms to other routes of administration.
Moderators
Balvinder S. Vig, Ph.D.
Bristol-Myers Squibb Company
Neil Mathias, Ph.D.
Bristol-Myers Squibb Company
Transdermals: Quo Vadis
Howard Maibach, M.D.
University of California, San Francisco
High Throughput Screening of Chemical Enhancer Formulations for Transdermal Drug Delivery
Samir Mitragotri, Ph.D.
University of California, Santa Barbara
Percutaneous Penetration Modifiers: Enhancement vs. Retardation
Bozena Michniak, Ph.D.
Rutgers University
Non-animal Approaches to the Assessment of Skin Irritation Potential
David Basketter, D.Sc.
St. Thomas’ Hospital