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  Protein Aggregation and Immunogenicity Focus Group

The Protein Aggregation and Immunogenicity Focus Group was formed to study protein aggregation and immunogenicity and to begin answering some questions that seemingly come up during every conference that is held on protein aggregation. Ideally and very globally, we are striving for an understanding of the qualitative and quantitative aspects of aggregation of therapeutic protein products in engendering various types of immune responses to product. As you know, such immune responses can be a major stumbling block to product development and have plagued even licensed protein therapeutics.

The goals are to 1) establish a core group of interested investigators; 2) define the questions that need to be answered to understand the impact of protein aggregation on immunogenicity; 3) establish a research plan to answer these questions; 4) establish which groups will be responsible for executing aspects of the research plan; and 5) convene to examine results, establish a group to write a manuscript based on results, and discuss follow-up studies. The membership of this group will contain experts in biophysical chemistry and in immungenicity.


Workshop on Protein Aggregation Meeting Presentations
September 26-27, 2006, Breckenridge, Colorado
Presented by the University of Colorado Center for Pharmaceutical Biotechnology, the AAPS Protein Aggregation and Immunogenicity Focus Group, and the U.S. Food and Drug Administration
  • Summary of Responses for Breakout Session Questions
  • Oral Presentations
  • Poster Presentations

  • JOIN THE PROTEIN AGGREGATION AND IMMUNOGENICITY FOCUS GROUP

    To join the Protein Aggregation and Immunogenicity Focus Group, click here.

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      Leadership

    Chair
    Dr. Satish K. Singh
    Pfizer, Inc.
    Chesterfield, MO United States



    Past Chair
    Mary Cromwell
    Genentech, Inc.
    South San Francisco, CA




    Click here to fill out a focus group membership form.

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