Selected Companies With a Focus on Genomics, Including Pharmacogenomics

Company

Web Address

Focus

ACLARA BioSciences, Inc

www.aclara.com

Lab card microfluidic technology

Affymetrix, Inc

www.affymetrix.com

GeneChip microarray technology

Aurora Bioscience Corp

www.aurorabio.com

Genomic and drug screening technology

Caliper Technologies Corp

www.clipertech.com

Microfluidic Lab Chip, SNP scanning (with Agilent)

Celera Genomics

www.celera.com

Human Genome sequencing and SNP scanning

Curagen Corp

www.curagen.com/

SNP scanning; Gene expression and drug response

Epidauros

www.epidauros.com/

Pharmacogenomics in drug discovery and therapy

Exelixis, Inc

www.exelixis.com

Model systems for drug discovery

Genaissance Pharmaceuticals, Inc

www.genaissance.com

Genetic polymorphism in cancer, vascular lesions

Gene Logic, Inc

www.genelogic.com

Gene expression databases

Genomic Solutions, Inc

www.genomesolutions.com/

Genomics

Incyte Pharmaceuticals, Inc

www.incyte.com

Bioinformatics, SNP scanning, functional genomics

Lion Bioscience, AG

www.lion-ag.de/

Bioinformatics, drug targets from gene expression

DNA Sciences, Inc.

www.dna.com

Pharmacogenetics services, discovery/development/commercialization

Lynx Therapeutics

www.lynxgen.com

Micro-bead based DNA/SNP scanning

Microcide Pharmaceuticals

www.microcide.com/

Microbial genomics and antibiotics

Mitokor, Inc

www.mitokor.com/

Mitochondrial genome analysis

Orchid Biocomputer, Inc

www.orchidbio.com

Microfluidic devices and pharmacogenetic testing

PE Biosystems, Inc

www.pebio.com

Genomics, drug discovery

Rosetta Inpharmatics

www.rii.com

Oligonucleotide array studies

Third Wave Technologies, Inc

www.twt.com

SNP scanning, pharmacogenomics

Transgenomic, Inc

www.transgenomic.com

Discovery of genetic variations

Variagenics, Inc

www.variagenics.com

Cancer therapeutics based on loss of heterozygosity

Web Sites Containing Pharmacogenomics Information

Description

URL

Human Genome Project (HGP)

www.ornl.gov/TechResources/Human_Genome/home.html

Glossary of Genetic Terms (NIH)

www.nhgri.nih.gov/DIR/VIP/Glossary

Primer on Molecular Genetics (JHMI)

www.bis.med.jhmi.edu.Dan/DOE/intro.html

Environmental Genome SNP Database and Research Platform

dir.niehs.nib.gov/egsnp/status/

National Center for Biotechnology Information

www.ncbi.nlm.nih.gov/SNP/

Orchid Biocomputer maintained SNP site

www.snps.com/

Stanford University Genome Resources

www-genome.stanford.edu/index.html

Weizmann Institute

bioinfo.weizmann.ac.il/

Whitehead Institute for Biomedical Research

www-genome.wi.mit.edu/

Genset, Inc, site

www.genxy.com/Science/index.html

SNP Consortium site

snp.cshl.org/

Human genic bi-allelic sequence database

hgbase.cgr.ki.se/

List of Relevant Databases and Links, Prepared by Maureen Cronin, Aclara

Description

URL

Weizmann Institute GeneCards

bioinfo.weizmann.ac.il/cards/

RxList - The Internet Drug Index

www.rxlist.com/

PCS Performance Drug List

www.druglist.com/

Drug Discovery Online

www.drugdiscoveryonline.com/content/homepage/default.asp

PharmInfoNet Drug Database

www.pharminfo.com/drugdb/db_mnu.html

Cytochrome P450 Drug Interaction

www.dml.georgetown.edu/depts/pharmacology/davetab.html

LocusLink SNP Database

www.ncbi.nlm.nih.gov/LocusLink/list.cgi

drkoop.com Personal Drugstore

www.drkoop.com/hcr/drugstore/drugchecker/drugchecker-popup.asp

OMIM Catalog of Genetic Diseases

www.ncbi.nlm.nih.gov/Omim/

900 SNPs in Hypertension Genes

www.ncbi.nlm.nih.gov/SNP/snp_search.cgi?searchType=byPub&pub_id=493

600 SNPs identified in Genbank alignments

www.ncbi.nlm.nih.gov/SNP/snp_search.cgi?searchType=byPub&pub_id=497

Database of ABC transporter genes

www.med.rug.nl/mdl/humanabc.htm

Cystathionine b-Synthase database

www.uchsc.edu/sm/cbs/cbsdata/cbsmain.htm

Fibrinogen database

www.geht.org/pages/database_fibrino_uk.html

Glanzmann Thrombasthenia Database

med.mssm.edu/glanzmannDB/

P450 (CYP) Allele Nomenclature Committee

www.imm.ki.se/cypalleles/

Mammalian Gene Mutation Database

lisntweb.swan.ac.uk/cmgt/index.htm

Tumor gene database

mbcr.bcm.tmc.edu//oncogene.html

EBI Sequence Variation Database

www2.ebi.ac.uk/mutations/

HGMD Human Gene Mutation Database (Cardiff)

www.uwcm.ac.uk/uwcm/mg/hgmd0.html

Listing of gene-specific databases

lisntweb.swan.ac.uk/cmgt/pages/databaselinks.htm

Yale Mutation Spectra Database

info.med.yale.edu/mutbase/

Oligo Properties Calculator

www.basic.nwu.edu/biotools/OligoCalc.html

Roche Mol. Biol. SW Tools

biochem.roche.com/prodinfo_fst.htm?/benchmate/

DNA synthesis calculator

www.syntheticgenetics.com/calculator.html

PrimerCalculator (Williamstone Enterprises)

www.williamstone.com/primers/calculator/

Chair
Majid Moridani, Pharm.D., Ph.D.
Texas Tech University Health Sciences Center
Amarillo, TX

Past Chair
Charles R. Yates, PhD
University of Tennessee
Memphis, TN UNITED STATES

Steering Committee Member
Madhu Cherukury, Ph.D
Allergan
Irvine, CA United States

Steering Committee Member
Christopher J. Destache
Creighton University
Omaha, NE UNITED STATES

Steering Committee Member
Lawrence L. Fleckenstein, Pharm.D.
University of Iowa College Of Pharmacy
Iowa City, IA

Steering Committee Member
Felix W. Frueh, Ph.D.
Medco Health Solutions, Inc.
Gaithersburg, MD

Steering Committee Member
Dr. Angela Keightley
Charles River Laboratories
Senneville, PQ CANADA

Steering Committee Member
Pramod Bapurao Mahajan
Drake University College of Pharmacy & Health Sciences
Des Moines, IA United States

Steering Committee Member
Ross Allan McKinnon
University of South Australia
Adelaide, AUSTRALIA

Steering Committee Member
Partha Roy, Ph.D.
US FDA
Silver Spring, MD UNITED STATES