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Purpose and Description
The Microdialysis Focus Group of the AAPS aims to be a stimulant and vehicle for the exchange of information and discussions on the microdialysis technique with respect to its important current applications and future potentials in quantitative drug research and development.
Within the last decades it has become clear that in vivo microdialysis is of unique value in quantitative pharmacological research. It is the only in vivo technique that is able to provide temporal information on local free concentrations of drugs and metabolites in the extracellular space at specific sites in the body. Thus, quantitative in vivo microdialysis studies have provided new information on drug delivery to, for example, the CNS and subcutaneous sites, on distribution to the liver, lung, muscle, adipose and other target tissues, as well as on the characterization of blood levels of drug and metabolites. The microdialysis technique is therefore closely connected to the research fields of drug delivery, drug metabolism, pharmacokinetics, and pharmacodynamics, while the state-of-art analytical technologies are needed, and expansion of microdialysis applications will follow progress in analytical technologies. This explains the Section Affiliations of the AAPS indicated above.
The Membership of the Microdialysis Focus Group is open to any AAPS member who has an interest in microdialysis, and in time, the Members has exceeded the number of 250. The Focus Group Chair and Steering Committee hope to serve the Microdialysis Focus Group Members by organizing podium and poster presentations, symposia, and other mechanisms for adequate exchange of information. We are very much open to suggestions from the Microdialysis Focus Group Members.
Programming
2008 AAPS Annual Meeting
Meetings of Interest
Report on:
5TH International Symposium on Microdialysis in Drug Research and Development
The 5TH International Symposium on Microdialysis in Drug Research and Development; “The Target Site in Focus”, was held in Leiden, the Netherlands, on April 25 – 27, 2007.
Kicked-off by Prof. dr. Ronald Sawchuk as a keynote speaker on “Future Perspectives on the Contributions of Microdialysis in Drug Research and Development”, the lectures in this symposium were of high quality and provided a clear overview of the current and future contributions of in vivo microdialysis in preclinical and clinical studies. Furthermore, the alive discussions and numerous posters with interesting frontline research added significantly to this very succesful meeting.
This symposium made clear that the appreciation of the microdialysis potential as the only technique that provides specifically insights in the behaviour of compounds in extracellular spaces of the body is continuously growing. By the progress in analytical methodologies that are able to deal with specific and selective analysis of many compounds in the typical small-volume-low-concentration microdialysis samples, especially by mass spectrometry, the breath of applications of the microdialysis technique is still expanding. The quantitative aspect of the microdialysis technique, which has always been a matter of concern, is viewing a bright future by the current further development of the ultraslow-dialysis concept. Furthermore, the combination of microdialysis with other techniques that provide insight into subtissue distribution is making considerable progress. Also, it was also shown that knowledge on membrane transport and extracellular target tissue concentrations when related to pharmacodynamics (PK-PD modelling) will help in clarifying what concentrations represent best and what mechanisms govern the target site concentrations. An extra dimension is the inclusion of disease in which biomarkers of disease condition may also be provided by microdialysis. Taken together it can be concluded that microdialysis contributes to increasing the efficiency in drug development, while it is anticipated that the future of microdialysis will be as bright as the sunny weather that all participants enjoyed during the meeting.
Impression (photos) at www.lacdr.nl/symposia
Meeting Minutes
Useful Web Links
Cutaneous Microdialysis Club is a non-profit interest group
for people working with microdialysis in the skin and
subcutaneous tissues. Can be contacted by mailing to
Lotte Groth
or
Eva Benfeldt
.
2007 Leadership
- Chair: Grazia Stagni (2007-2009)
- Chair-elect: Thomas Cremers (2009-2011)
- Past Chair: Elizabeth de Lange (2005-2007)
2008 Steering Committee Members
- William Kielbasa (2006-2008)
- Robert Stratford (2006-2008)
- Chinmay Shukla (2006-2008)
- Emilio Squillante (2006-2008)
- Jasper Stevens (2007-2009)
Contact
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Ms. Grazia Stagni, Ph.D.
Long Island University
75 DeKalb Ave.
Brooklyn, NY 11201-5497
Work Phone: (718) 488-1231
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Dr. Thomas Cremers
Brains On-line
Antonius Deusinglaan 1
Groningen, 9713 AV, NETHERLANDS
Work Phone: (415) 623-0526
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Ms. Elizabeth De Lange, Ph.D.
LACDR / Division of Pharmacology
Gorlaeus Laboratories Postbus 9502
Leiden, 2300 RA, NETHERLANDS
Work Phone: 071-5276330
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William Kielbasa, Ph.D.
Lilly Research Laboratories
Lilly Corporate Center
Indianapolis, IN 46285
Work Phone: (317) 277-2788
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Robert E. Stratford, Jr., Ph.D.
Lilly Research Laboratories
Lilly Corporate Center
Indianapolis, IN 46285
Work Phone: (317) 276-4190
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Chinmay Shukla, MS (Ph.D.)
Division of Pharmaceutical Sciences
Long Island University
75 DeKalb Ave
Brooklyn, NY 11201-5497
Work Phone: (646) 261-9733
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Emilio Squillante, Ph.D.
St. John's University
8000 Utopia Pkwy. 105 SAH
Dept. Of Pharmacy Admin. Services
Jamaica, NY 11439
Work Phone: (718) 990-5020
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Jasper Stevens
Leiden/Amsterdam Center for Drug Research
Einsteinweg 55, room 812b
2333 CC LEIDEN
NETHERLANDS
Work Phone: 003(171) 527-6071
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JOIN THE MICRODIALYSIS FOCUS GROUP
To join the Microdialysis Focus Group, click here.
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